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A 2025 review in Pharmaceuticals put it bluntly: There are obvious differences between the physiologies of rodents and humans

People who are more insulin-resistant need a higher dose of insulin to maintain their blood glucose levels within the normal range

In this case, the B12 shots have started to heal the damaged neurons myelin sheath, but the neural network in which the healed neuron is in, is in a super sensitive state (with extra receptors), so the patient may feel pain or other unpleasant sensations

Your body doesnt make B12 on its own

Injecting patients with B12 may have an effect on the persons metabolism and increase energy

It supports: Red blood cell production helping to prevent anaemia and improve oxygen flow